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N-Acetyl-Ser-Asp-Lys-Pro inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.
C S Anthony; G Masuyer; E D Sturrock; K R Acharya. Structure based drug design of angiotensin-I converting enzyme inhibitors. Current Medicinal Chemistry.2012, 19, (6), 845-855.
A Rousseau-Plasse; J Wdzieczak-Bakala; M Lenfant; E Ezan, R Genet; S Robinson; T Briscoe; J Melville; A Riches. Lisinopril, an angiotensin I-converting enzyme inhibitor, prevents entry of murine hematopoietic stem cells into the cell cycle after irradiation in vivo. Experimental Hematology.1998, 26, (11), 1074-1079.
Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.