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99534-03-9 - cAMP Dependent Protein Kinase Inhibitor (PKI 5-24) - Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp - J66438 - Alfa Aesar

J66438 cAMP Dependent Protein Kinase Inhibitor (PKI 5-24)

CAS Number
99534-03-9
Synonyms
Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp

Size Price ($) Quantity Availability
1mg 130.00
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cAMP Dependent Protein Kinase Inhibitor (PKI 5-24)

MDL
MFCD00133989

Chemical Properties

Formula
C94H148N32O31
Formula Weight
2222.40
Form
Solid
Solubility
Soluble in water

Applications

cAMP Dependent Protein Kinase Inhibitor (PKI 5-24) acts as inhibitor of c-AMP-dependent protein kinase These proteins bind to the catalytic subunit of cyclic-AMP dependent protein kinase, displacing the regulatory subunit and inhibiting phosphorylating activity. The cyclic-AMP binding capacity of the regulatory subunit is enhanced.

Notes

Store at -20°C. Incompatible with heat and oxidizing agents.

Literature References

H C Cheng; B E Kemp; R B Pearson; A J Smith; L Misconi; S M Van Patten; D A Walsh. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. Journal of Biological Chemistry.1986, 261, (3), 989-992.

Haowei Song; Henry Rohrs; Min Tan; Mary Wohltmann; Jack H Ladenson; John Turk. Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin. Journal of Biological Chemistry.2010, 285, (44), 33843-33857.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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