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D-Fructose-1,6-diphosphate dicalcium salt is essential for glycolysis to occur efficiently. It links to adenine nucleotides which regulate 6-phosphofructokinases (Pfks) that catalyze one of the rate limiting steps of glycolysis.
Shinya Fushinobu; Hiroshi Nishimasu; Daiki Hattori; Hyun-Jin Song; Takayoshi Wakagi. Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase. Nature.2011, 478, (7370), 538-541.
Jacques-Philippe Colletier; Alexey Aleksandrov; Nicolas Coquelle; Sonia Mraihi; Elena Mendoza-Barberá; Martin Field; Dominique Madern. Sampling the conformational energy landscape of a hyperthermophilic protein by engineering key substitutions. Molecular Biology and Evolution.2012, 29, (6), 1683-1694.