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Cathepsin D, human liver is useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. It contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. It is a useful prognostic indicator for breast cancer.
J Higaki, R Catalano; A W Guzzetta; D Quon; J F Navé; C Tarnus; H D'Orchymont; B Cordell. Processing of beta-amyloid precursor protein by cathepsin D. Journal of Biological Chemistry.1993, 271, (50), 31885-31893.
A J Barrett. Cathepsin D. Purification of isoenzymes from human and chicken liver. Biochemical Journal.1970, 117, (3), 601-607.