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Oxaliplatin is an anti-tumor agent with activity against colorectal cancer. It shows antitumor activity in cell lines with acquired cisplatin resistance. It is used to treat cancer of the gullet (oesophagus). It is used as adjuvant therapy in patients who have had surgery to remove the cancer. It is used to treat testicular cancer.
D Khayat; M Gil-Delgado; E C Antoine; D Nizri; G Bastian. The role of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer. Oncology (Williston Park, N.Y.).2001, 15, (4), 414-415.
Peter Draxler; Silke Doris Honsek; Liesbeth Forsthuber; Viktoria Hadschieff; Jürgen Sandkühler. VGluT3? primary afferents play distinct roles in mechanical and cold hypersensitivity depending on pain etiology. Journal of Neuroscience.2014, 34, (36), 12015-12028.
Hazard Statements: H315-H317-H319-H334-H335-H341-H351
Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation. Suspected of causing genetic defects. Suspected of causing cancer.
Precautionary Statements: P201-P202-P264b-P271-P272-P280-P281-P285-P302+P352-P304+P340-P305+P351+P338-P308+P313-P333+P313-P342+P311-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. In case of inadequate ventilation wear respiratory protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. If skin irritation or rash occurs: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant