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Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.
C. Queille-Roussel.; C. Paul, L. Duteil.; M-C. Lefebvre.; G. Rapatz.; M. Zagula.; J-P. Ortonne. The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study.British Journal of Dermatology. 2001, 144 (3),507-513 .
Hazard Statements: H302-H312-H332
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Precautionary Statements: P261-P280h-P304+P340-P301+P312a-P321-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Specific treatment (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.