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104987-12-4 - Ascomycin, 95% - Immunomycin - FK-520 - J66751 - Alfa Aesar

J66751 Ascomycin, 95%

CAS Number
104987-12-4
Synonyms
Immunomycin
FK-520

Size Price ($) Quantity Availability
25mg 132.80
100mg 526.33
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Ascomycin, 95%

MDL
MFCD06198665

Chemical Properties

Formula
C43H69NO12
Formula Weight
790
Form
Powder
Melting point
156-160°
Boiling Point
868°
Flash Point
>110°(230°F)
Solubility
Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water

Applications

Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

C. Queille-Roussel.; C. Paul, L. Duteil.; M-C. Lefebvre.; G. Rapatz.; M. Zagula.; J-P. Ortonne. The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study.British Journal of Dermatology. 2001, 144 (3),507-513 .

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H332

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Precautionary Statements: P261-P280-P264-P270-P304+P340-P301+P312-P312-P363-P322-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Specific measures (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2941.90
TSCA
No
RTECS
KD4185000

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