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Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts.
Yannis Dotsikas.; Yannis L Loukas. Kinetic degradation study of insulin complexed with methyl-beta cyclodextrin. Confirmation of complexation with electrospray mass spectrometry and 1H NMR. J. Pharm. Biomed. Anal. 2002, 29 (3),487-494 .
Hazard Statements: H317-H361
May cause an allergic skin reaction. Suspected of damaging fertility or the unborn child.
Precautionary Statements: P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF exposed or concerned: Get medical advice/attention. If skin irritation or rash occurs: Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant