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Ceftiofur sodium is resistant to the antibiotic resistance enzyme beta-lactamase, and has activity against Gram-positive and Gram-negative bacteria. E. coli strains resistant to ceftiofur have been reported. The bactericidal activity of ceftiofur results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins. The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall component from being properly synthesized.
Beate G. Rose.; Carol Kamps-Holtzapple.; Larry H. Stanker. Competitive Indirect ELISA for Ceftiofur Sodium and the Effect of Different Immunizing and Coating Antigen Conjugates. Bioconjugate Chem. 1995, 6, (5), 529-535.
Hazard Statements: H317-H334
May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statements: P272-P280g-P285-P302+P352-P304+P341-P333+P313-P342+P311-P363-P501c
Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. In case of inadequate ventilation wear respiratory protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. If skin irritation or rash occurs: Get medical advice/attention. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant