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75747-14-7 - 17-(Allylamino)-17-demethoxygeldanamycin, 99% - 17-AAG - 17-(Allylamino)geldanamycin - J66960 - Alfa Aesar

J66960 17-(Allylamino)-17-demethoxygeldanamycin, 99%

CAS Number
75747-14-7
Synonyms
17-AAG
17-(Allylamino)geldanamycin

Size Price ($) Quantity Availability
25mg 74.16
100mg 140.94
200mg 271.92
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17-(Allylamino)-17-demethoxygeldanamycin, 99%

MDL
MFCD04973892

Chemical Properties

Formula
C31H43N3O8
Formula Weight
585.69
Form
Solid
Melting point
207-209°
Flash Point
>110°(230°F)
Sensitivity
Light Sensitive
Solubility
Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water

Applications

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

Theodor W. Schulte.; Leonard M. Neckers. The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemotherapy and Pharmacology. 1998, 42, (4), 273-279.

Merrill J. Egorin.; Eleanor G. Zuhowski.; Marc Rosen, D.; Dorothy L. Sentz.; Joseph M. Covey.; Julie L. Eiseman. Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1. Cancer Chemotherapy and Pharmacology. 2001, 47, (4), 291-302.

Other References

Harmonized Tariff Code
2941.90
TSCA
No
RTECS
LX8932000

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