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Endothelin 1 has been used for coating wells in polystyrene ELISA plates. Potent agonist for ETA and ETB endothelia receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
Stephen A. Douglas.; C. Robin Hiley. Responses to endothelin-1, human proendothelin (1-38) and porcine proendothelin (1-39) in the rat on intravenous administration and in the blood perfused mesentery. Neurochemistry International. 1991, 18, (4), 445-454.