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126411-39-0 - SR-12813, 98% - Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate - J67136 - Alfa Aesar

J67136 SR-12813, 98%

CAS Number
126411-39-0
Synonyms
Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate

Size Price ($) Quantity Availability
10mg 125.00
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SR-12813, 98%

MDL
MFCD00888473

Chemical Properties

Formula
C24H42O7P2
Formula Weight
504.54
Form
Solid
Melting point
119-121°
Solubility
Soluble in DMSO at 25mg/ml

Applications

R-12813 was used as control in pregnane X receptor (PXR) binding assay performed in HepG2 liver carcinoma cells and PXR-activation assay mediated by dehydroepiandrosterone in human hepatocytes. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase. This compound is a featured product for Gene Regulation research.

Notes

Store at -4°C. Incompatible with heat, oxidizing agents.

Literature References

Theo A Berkhout.; Helen M Simon.; Brian Jackson.; John Yates.; Nigel Pearce.; Pieter H.E Groot.; Craig Bentzen.; Eric Niesor.; William D Kerns.; Keith E Suckling. SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis.Atherosclerosis. 1997, 133 (2),203-212 .

GHS Hazard and Precautionary Statements

Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2931.39
TSCA
No

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