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R-12813 was used as control in pregnane X receptor (PXR) binding assay performed in HepG2 liver carcinoma cells and PXR-activation assay mediated by dehydroepiandrosterone in human hepatocytes. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase. This compound is a featured product for Gene Regulation research.
Theo A Berkhout.; Helen M Simon.; Brian Jackson.; John Yates.; Nigel Pearce.; Pieter H.E Groot.; Craig Bentzen.; Eric Niesor.; William D Kerns.; Keith E Suckling. SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis.Atherosclerosis. 1997, 133 (2),203-212 .