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Zeocin, a popular and effective antibiotic for the selection of vectors bearing the Sh ble gene in a variety of cells types (bacteria, eukaryotic microorganisms, plant and animal cells). Resistance to Zeocin is conferred by the Sh ble gene product, which inactivates Zeocin by binding to the antibiotic. Sh ble is a small gene, only 370bp in size, carried in a number of InvivoGens vectors. Zeocin is used as a selective agent in molecular genetics experiments.
TA Pfeifer.; DD Hegedus.; TA Grigliatti.; DA Theilmann. Baculovirus immediate-early promoter-mediated expression of the Zeocin resistance gene for use as a dominant selectable marker in Dipteran and Lepidopteran insect cell lines. Gene. 1997, 188, (2), 183-190.
S Takeno.; E Sakuradani.; A Tomi. Transformation of oil-producing fungus, Mortierella alpina 1S-4, using Zeocin, and application to arachidonic acid production. Journal of Bioscience and Bioengineering. 2005, 100, (6), 617-622.
Hazard Statements: H341
Suspected of causing genetic defects.
Precautionary Statements: P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.