A cell permeable and selective inhibitor of the cyclin-dependent kinases Cdk1/cyclin B, Cdk2 and Cdk5. The inhibitory effect butyrolactone I is due to competition with ATP binding at the Cdk. Butyrolactone I inhibits cell cycle progression at the G1/S and G2/M transitions. Butyrolactone I also blocks Fas-induced apoptosis.
A tool for probing the cellular roles of cyclin-dependent kinases. A selective inhibitor of CDK1/cyclin B, CDK2 and CDK5.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.