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87414-49-1 - Butyrolactone I, 98% - J67151 - Alfa Aesar

J67151 Butyrolactone I, 98%

A cell permeable and selective inhibitor of the cyclin-dependent kinases Cdk1/cyclin B, Cdk2 and Cdk5. The inhibitory effect butyrolactone I is due to competition with ATP binding at the Cdk. Butyrolactone I inhibits cell cycle progression at the G1/S and G2/M transitions. Butyrolactone I also blocks Fas-induced apoptosis.

CAS Number
87414-49-1
Synonyms

Size Price ($) Quantity Availability
200microg 136.08
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Butyrolactone I, 98%

MDL
MFCD03453074

Chemical Properties

Formula
C24H24O7
Formula Weight
424.45
Form
Solid
Melting point
74°
Sensitivity
Light Sensitive
Solubility
Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml

Applications

A tool for probing the cellular roles of cyclin-dependent kinases. A selective inhibitor of CDK1/cyclin B, CDK2 and CDK5.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2932.20
TSCA
No
RTECS
LU0221600

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