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J67151 Butyrolactone I, 98%

A cell permeable and selective inhibitor of the cyclin-dependent kinases Cdk1/cyclin B, Cdk2 and Cdk5. The inhibitory effect butyrolactone I is due to competition with ATP binding at the Cdk. Butyrolactone I inhibits cell cycle progression at the G1/S and G2/M transitions. Butyrolactone I also blocks Fas-induced apoptosis.

CAS Number
87414-49-1
Synonyms

Stock No. Size Price ($) Quantity Availability
J67151-&H 200microg 162.00
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Butyrolactone I, 98%

MDL
MFCD03453074

Chemical Properties

Formula
C24H24O7
Formula Weight
424.45
Form
Solid
Melting point
74°
Storage & Sensitivity
Store at -20°C. Light Sensitive.
Solubility
Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml

Applications

A tool for probing the cellular roles of cyclin-dependent kinases. A selective inhibitor of CDK1/cyclin B, CDK2 and CDK5.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2932.20
TSCA
No
RTECS
LU0221600

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