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Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm?s tumor and the sarcomas.
Perry, R.P. Selective effects of actinomycin D on the intracellular distribution of RNA synthesis in tissue culture cells.Experimental Cell Research. 1963, 29, (3), 400-406.
Paul R. Gross.; Gilles H. Cousineau. Effects of actinomycin D on macromolecule synthesis and early development in sea urchin eggs.Biochemical and Biophysical Research Communications. 1963, 10, (4), 321-326.
Hazard Statements: H227
Precautionary Statements: P210u-P280a-P370+P378a-P403+P235-P501a
Wear protective gloves and eye/face protection. In case of fire: Use for extinction: CO2, powder or water spray. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.