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J67193 Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered

CAS Number

Stock No. Size Price ($) Quantity Availability
J67193-XF 1ml 274.00
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Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered


Chemical Properties

Storage & Sensitivity
Store at -20°C.
Soluble in methanol, ethanol (0.1 mg/ml), DMSO (0.1 mg/ml), acetone, and chloroform. Insoluble in water.


Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type H+ ATPase). The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.


Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

E. Papini.; M. Bugnoli.; M. De Bernard.; N. Figura.; R. Rappuoli.; C. Montecucco. Bafilomycin A1 inhibits Helicobacter pylori-induced vacuolization of HeLa cells.Mol. Microbiol. 1993, 7 (2),.1365-2958 .

Daniel J. Klionsky.; Zvulun Elazar.; Per O. Seglen.; David C. Rubinsztein. Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy. 2008, 4 (7),849-850 .

GHS Hazard and Precautionary Statements

Hazard Statements: H227

Combustible liquid.

Precautionary Statements: P210-P280-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

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