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Nalidixic acid is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. It is used to modulate (inhibit) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent)t DNA supercoiling, and chromosome fragmentation.
Martin Gellert.; Kiyoshi Mizuuchi.; Mary H. O'Dea.; Tateo Itoh.; Jun-Ichi Tomizawa. Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity.pnas. 1977, 74 (11), 4772-4776 .
Hazard Statements: H317-H334
May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statements: P261-P272-P280g-P285-P302+P352-P304+P341-P333+P313-P342+P311-P363-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. In case of inadequate ventilation wear respiratory protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. If skin irritation or rash occurs: Get medical advice/attention. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant