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Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage.
Xiaoying Yang.; Xiaoyan Zhang.; Zunfeng Liu.; Yanfeng Ma.; Yi Huang.; Yongsheng Chen.High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide. J. Phys. Chem. C. 2008, 112 (45),17554-17558 .
Xiuling Xu.; Xuesi Chen.; Pingan Ma.; Xinri Wang.; Xiabin Jing. The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning.European Journal of Pharmaceutics and Biopharmaceutics. 2008, 70 (1),165-170 .
Hazard Statements: H340-H350
May cause genetic defects. May cause cancer.
Precautionary Statements: P201-P202-P281-P308+P313-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/attention. Dispose of contents/ container to an approved waste disposal plant