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25316-40-9 - Doxorubicin hydrochloride, 10 mg/ml in DMSO, sterile filtered - J67209 - Alfa Aesar

J67209 Doxorubicin hydrochloride, 10 mg/ml in DMSO, sterile filtered

CAS Number
25316-40-9
Synonyms

Size Price ($) Quantity Availability
1ml 252.00
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Doxorubicin hydrochloride, 10 mg/ml in DMSO, sterile filtered

MDL
MFCD00077757
EINECS
246-818-3

Chemical Properties

Form
Liquid
Solubility
Soluble in water (50 mM), methanol, isotonic sodium chloride, and DMSO (>10 mg/ml). Insoluble in chloroform, and ether.

Applications

Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

Xiaoying Yang.; Xiaoyan Zhang.; Zunfeng Liu.; Yanfeng Ma.; Yi Huang.; Yongsheng Chen.High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide. J. Phys. Chem. C. 2008, 112 (45),17554-17558 .

Xiuling Xu.; Xuesi Chen.; Ping’an Ma.; Xinri Wang.; Xiabin Jing. The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning.European Journal of Pharmaceutics and Biopharmaceutics. 2008, 70 (1),165-170 .

GHS Hazard and Precautionary Statements

Hazard Statements: H350

May cause cancer.

Precautionary Statements: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2941.90
TSCA
No
RTECS
QI9295900

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