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Blasticidin S hydrochloride, acts quickly by inhibiting peptide bond formation by the ribosome. The blasticidin S resistance gene (BSR), found in Bacillus cereus K55-S1, has been used in multiple studies for its use as a selective compound. Resistance is conferred by expression of one of two Blasticidin S deaminase genes: BSD from Aspergillus terreus or bsr from Bacillus cereus. These deaminases convert Blasticidin S to a nontoxic deaminohydroxy derivative. Blasticidin S is used for the prevention of contamination of cell cultures.
Masanori Sugiyama; Akinori Takeda; Soon-Young Paik; Osamu Nimi; Ryosaku Nomi. Acetylation Of Blasticidin S By Its Producing Actinomycetes. The Journal of Antibiotics. 1986, 39 (6), 827-832.
Kazutoshi Takahashi; Keisuke Okita; Masato Nakagawa & Shinya Yamanaka. Induction of pluripotent stem cells from fibroblast cultures. Nature Protocols. 2007, 2 3081 - 3089.