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67-66-3 - Chloroform, Molecular Biology Reagent - Trichloromethane - J67241 - Alfa Aesar

J67241 Chloroform, Molecular Biology Reagent

CAS Number
67-66-3
Synonyms
Trichloromethane

Size Price ($) Quantity Availability
500ml 53.80
1L 90.30
2.5L 184.00
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Chloroform, Molecular Biology Reagent

MDL
MFCD00000826
EINECS
200-663-8

Chemical Properties

Formula
CHCl3
Formula Weight
119.38
Form
Liquid
Melting point
-63°
Boiling Point
61°
Density
1.492
Refractive Index
1.446
Solubility
Soluble in water at 20°C 8 g/L.

Applications

Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is also used in organic synthesis as a source for CCl2. In the swine tracheal smooth muscle, chloroform has been demonstrated to directly and in a concentration dependent manner induce contractions. It has been observed that Chloroform can release Ca2+ from ryanodine sensitive receptors in chloroform-induced contraction in swine tracheal smooth muscle. At concentrations of 100 and 250 ppm in mouse splenocyte, basal proliferation was increased yet a decrease in circulating neutrophils was documented.

Notes

Stabilized with approx. 50 ppm amylene

Literature References

Auttachoat W, et al. Immunotoxicological profile of chloroform in female B6C3F1 mice when administered in drinking water.Drug Chem. Toxicol.,2009,32(1), 77-87.

Lin YR, et al. Role of ryanodine receptors in chloroform-induced contraction in Swine tracheal smooth muscle.Toxicol Appl Pharmacol.,2002,183(2), 146-51.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H331-H315-H319-H351-H361-H372

Harmful if swallowed. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. Suspected of causing cancer. Suspected of damaging fertility or the unborn child. Causes damage to organs through prolonged or repeated exposure.

Precautionary Statements: P260-P201-P280-P305+P351+P338-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2141
Beilstein
1731042
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2903.13
TSCA
Yes
RTECS
FS9100000

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