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3039-71-2 - U-18666A, 95% - 3beta-[2-(Diethylamino)ethoxy]androstenone hydrochloride - J67389 - Alfa Aesar

J67389 U-18666A, 95%

CAS Number
3039-71-2
Synonyms
3beta-[2-(Diethylamino)ethoxy]androstenone hydrochloride

Size Price ($) Quantity Availability
5mg 72.31
10mg 116.64
25mg 293.00
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U-18666A, 95%

MDL
MFCD00210908

Chemical Properties

Formula
C25H41NO2•HCl
Formula Weight
424.06
Form
Solid
Solubility
Soluble in water at 10mg/ml

Applications

Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.

Notes

Protect from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep it refrigerated.

Literature References

Koh, C.H.V, et al. Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: Bridging Niemann-Pick disease type C and Alzheimer’s disease.Cell Signal.,2006,18(11), 1844-1853.

Tabas, I. Apoptosis and plaque destabilization in atherosclerosis: The role of macrophage apoptosis induced by cholesterol.Cell Death Differ.,2004,11S12-S16.

Other References

Harmonized Tariff Code
2937.29
TSCA
No

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