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It is used for the solubilization and reconstitution of membrane-bound proteins. The high critical micelle concentration (0.7%) of n-octylglucoside facilitates ready removal from final protein extracts by dialysis or gel filtration. n-Octylglucoside can be used in 2D electrophoresis and to improve selectivity of immunoprecipitation of phosphotyrosine modified proteins. Also useful in 2D electrophoresis and in an immunoprecipitation buffer for the immunopurification of phospho-tyrosine peptides.
Zhang, G, et al. Use of detergents to increase selectivity of immunoprecipitation of tyrosine phosphorylated peptides prior to identification by MALDI quadrupole-TOF MS.Proteomics.,2006,6(2), 571-578.
Petri, W.A and Wagner, R.R. Reconstitution into liposomes of the glycoprotein of vesicular stomatitis virus by detergent dialysis. Biol Chem.,1979,254(11), 4313-4316.