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180002-83-9 - GW-405833 - L-768242 - 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]indole - J67425 - Alfa Aesar

J67425 GW-405833

CAS Number
180002-83-9
Synonyms
L-768242
1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]indole

Size Price ($) Quantity Availability
10mg 193.64
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GW-405833

MDL
MFCD09832650

Chemical Properties

Formula
C23H24Cl2N2O3
Formula Weight
447.36
Form
Solid
Melting point
47-49°
Solubility
Soluble in DMSO at 10-15mg/ml. Also soluble in ethanol at ~5mg/ml.

Applications

It is a potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.

Notes

Protect from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store in refrigerator at -20°C.

Literature References

LaBuda CJ, et al. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain.Eur J Pharmacol.,2005,527(1-3), 172-4.

Valenzano KJ, et al. Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.Neuropharmacology.,2005,48(5), 658-72.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H413

Toxic if swallowed. May cause long lasting harmful effects to aquatic life.

Precautionary Statements: P273-P264-P270-P301+P310-P321-P330-P405-P501a

Avoid release to the environment. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.99
TSCA
No

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