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J67498 Anisomycin, 10 mg/ml in DMSO, sterile-filtered

CAS Number
22862-76-6
Synonyms
Flagecidin

Stock No. Size Price ($) Quantity Availability
J67498-XF 1ml 177.00
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Anisomycin, 10 mg/ml in DMSO, sterile-filtered

MDL
MFCD00077650
EINECS
245-269-7

Chemical Properties

Form
Liquid
Storage & Sensitivity
Store at -20°C.
Solubility
Fully miscible in water. Soluble to 50 mM in ethanol and to 100 mM in DMSO. Soluble in methanol (20 mg/ml clear, faint yellow solution).Slightly soluble in alcohols, esters, ketones, chloroform, benzene, toluene, hexane, and ethyl acetate (10 mg/ml clear, colorless solution), DMF (20 mg/ml), and PBS pH 7.2 (0.5 mg/ml).

Applications

It is applied as an antiparasitic agent and antineoplastic agent. It acts as a protein synthesis inhibitor (blocks translation), potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. It also scts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD). Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).

Notes

Protect from heat, acids, reducing agents, acid chlorides and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep it refrigerated at -20°C and keep ignition sources away.

Literature References

Cano E, et al. Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.Mol Cell Biol.,1994,14,(11), 7352-62.

Grollman, A.P. Inhibitors of protein biosynthesis.J Biol Chem.,1967,242,(13), 3226-3233.

GHS Hazard and Precautionary Statements

Hazard Statements: H227

Combustible liquid.

Precautionary Statements: P210-P280-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2941.90
TSCA
No
RTECS
BZ9800000

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