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Anionic Acid Labile Surfactant I (AALS I), Certified Mass Spec Grade - J67647 - Alfa Aesar

J67647 Anionic Acid Labile Surfactant I (AALS I), Certified Mass Spec Grade

At neutral pH, Anionic Acid Labile Surfactant I acts as a detergent for use in sample preparation, protein solubilization, and cell lysis protocols. It is an alternative to SDS and other commonly used anionic detergents for protein analysis. When experimental solutions are adjusted to a pH of 2.5 - 3 with trifluoroacetic acid (TFA) and incubated for 10 minutes, the acid labile surfactant is fully cleaved into small organic molecules that do not exhibit surfactant activity or interfere with mass spectrometry analysis. The detergent is compatible with ESI and MALDI mass spectrometry analysis.

CAS Number

Size Price ($) Quantity Availability
5mg 235.00
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Anionic Acid Labile Surfactant I (AALS I), Certified Mass Spec Grade

Chemical Properties

Lyophilized Powder


This detergent is effective at solubilizing peptides and proteins, optimizing enzymatic digestions, and reducing surface adsorption losses via non-specific interactions


Exhibits fast degradation kinetics at acidic pH's between 2.0 to 3.0. The critical micellular concentration (CMC) is 7.7mM.

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