tert-Butyl cyanoacetate is used in the synthesis of vinylogous urea. It is also used as a new additive for the sugar nucleoside base coupling step en route to DAPD with improved β-selectivity.
Ivan L Pinto.; Richard L Jarvest.; Halina T Serafinowska. The synthesis of 5-alkoxy and 5-amino substituted thiophenes. Tetrahedron Letters. 2000, 41, (10), 1597-1600.
Reenu Sirohia.; Dong Hee Kimb.; Soo-Chang Yub.; Sang Hee Lee. Novel di-anchoring dye for DSSC by bridging of two mono anchoring dye molecules: A conformational approach to reduce aggregation. Dyes and Pigments. 2012, 92, (3), 1132-1137.
Alternative to Ethyl cyanoacetate, A11498, permitting non-hydrolytic decarboxylative cleavage of the ester group: Arkiv. Kemi., 23, 453 (1965); cf J. Am. Chem. Soc., 74, 831 (1952).
Hazard Statements: H227-H302
Combustible liquid. Harmful if swallowed.
Precautionary Statements: P210u-P280a-P264-P301+P312a-P403+P235-P501a
Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF SWALLOWED: Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.