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2466-76-4 - 1-Acetylimidazole, 98% - L00137 - Alfa Aesar

L00137 1-Acetylimidazole, 98%

CAS Number
2466-76-4
Synonyms

Size Price ($) Quantity Availability
5g 17.00
25g 33.20
100g 89.30
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1-Acetylimidazole, 98%

MDL
MFCD00005287
EINECS
219-577-7

Chemical Properties

Formula
C5H6N2O
Formula Weight
110.12
Melting point
98-104°
Sensitivity
Moisture Sensitive
Solubility
Hydrolyzes in water. Solubility in methanol (almost transparency).

Applications

It is a mild acylating agent and its reactivity can be enhanced by quaternization with, e.g. benzyl bromide. 1-Acetylimidazole was used as acetylation reagent for amino groups. It was also employed for acetylation of histones. It is relatively specific reagent for tyrosyl residue acetylatioa dn a reagent used in the synthesis of annulated imidazole derivatives.

Notes

Moisture sensitive. Store away from water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas.

Literature References

Feucht W, et al. Variation of the nuclear, subnuclear and chromosomal flavanol deposition in hemlock and rye.Int. J. Mol. Sci.,2007,8,(7), 635-50.

Marburg S and Jencks WP. The Solvolysis of 1-Acetylimidazole in Concentrated Acid and Salt Solutions.J. Am. Chem. Soc.,1962,84,(2), 232-39.

Mild acylating agent. Reactivity can be enhanced by quaternization with, e.g. benzyl bromide: Chem. Pharm. Bull., 30, 4242 (1982). Acylation of nitromethane salts leads to acylnitro compounds: Synthesis, 478 (1978).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
108425
Harmonized Tariff Code
2933.29
TSCA
Yes
RTECS
NI3400000

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