I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Oxazolines were introduced by Meyers as intermediates for synthesis of ß-hydroxy acids or esters, by alkylation of the lithio-derivative and cleavage of the ring. Similarly, addition to carbonyl compounds leads, under dehydrating conditions (strong acid) to the corresponding acrylic acids: J. Org. Chem., 39, 2778 (1974):/n
Reaction with epoxides leads to -butyrolactones: J. Org. Chem., 39, 2783 (1974)./n
Substituted ß-keto esters can be prepared by reaction with an acid chloride followed by the introduction of further substituents by alkylation of the acylated oxazoline in DMF: Bull. Chem. Soc. Jpn., 57, 2329 (1984):/n
For reviews of the chemistry of oxazolines, see: Chem. Rev., 71, 483 (1971); Angew. Chem. Int. Ed., 15, 270 (1976), Tetrahedron, 41, 837 (1985); 50, 2297 (1994)./n
Hazard Statements: H225
Highly flammable liquid and vapour.
Precautionary Statements: P210-P280a-P240-P241-P303+P361+P353-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Dispose of contents/container in accordance with local/regional/national/international regulations.