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937-14-4 - 3-Chloroperoxybenzoic acid, 50-55%, cont. ca 10% 3-chlorobenzoic acid, balance water - m-Chloroperbenzoic acid - mCPBA - L00286 - Alfa Aesar

L00286 3-Chloroperoxybenzoic acid, 50-55%, cont. ca 10% 3-chlorobenzoic acid, balance water

CAS Number
m-Chloroperbenzoic acid

Size Price ($) Quantity Availability
25g 27.33
100g 77.31
500g 247.20
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3-Chloroperoxybenzoic acid, 50-55%, cont. ca 10% 3-chlorobenzoic acid, balance water


Chemical Properties

Formula Weight
Melting point
Soluble in potassium hydroxide, chloroform and acetone. Insoluble in water.


3-Chloroperoxybenzoic acid is a strong oxidizing agent used in the oxidation reactions such as aldehydes and ketones to esters (Bayer-Villiger-Oxidation), olefines to epoxides, sulfides to sulfoxides and sulfones, and amines to nitroalkanes, N-oxides.


Heat sensitive. Incompatible with reactive with reducing agents, combustible materials, organic materials and alkalies.

Literature References

Reagent for epoxidation of alkenes: J. Org. Chem., 29, 1976 (1964). Dichloromethane has been recommended as solvent for these reactions, since the peracid is soluble, but the by-product, 3-chlorobenzoic acid, is almost insoluble. For high-yield, stereospecific epoxidation in a two-phase, almost neutral system, see: J. Org. Chem., 44, 1351 (1979). For regioselective epoxidation of the more substituted double bond of a diene, see: Org. Synth. Coll., 5, 467 (1973). For epoxidation in aqueous solution followed by in situ hydrolysis to the trans-diol by 10% sulfuric acid, see: Synth. Commun., 19, 1939 (1989).

Carbonyl compounds undergo the Baeyer-Villiger reaction to give esters or lactones: J. Org. Chem., 29, 2914 (1964). For an extensive review of the Baeyer-Villiger reaction, see: Org. React., 43, 251 (1993).

Primary aliphatic amines are oxidized to nitro-compounds: J. Org. Chem., 31, 524 (1966). Good yields are obtained in 1,2-dichloroethane solution: J. Org. Chem., 44, 659 (1979); 54, 2869 (1989).

Sulfides can be oxidized selectively either to sulfoxides or sulfones: Tetrahedron, 22, 1235 (1966); J. Chem. Soc. (C), 2720 (1969); J. Org. Chem., 35, 2106 (1970).

For the stereospecific oxidation of imines to oxaziridines under phase-transfer conditions, see: Org. Synth. Coll., 8, 546 (1993):

Perfluorooxaziridines have been prepared using acetonitrile as solvent: J. Org. Chem., 58, 4754 (1993).

For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 664 (2007).

WARNING: The reagent has been reported to react exothermically with DMF: Org. Process Res. Dev., 6, 159 (2004).

Ernould, B.; Devos, M.; Bourgeois, J.; Rolland, J.; Vlad, A.; Gohy, J. Grafting of a redox polymer onto carbon nanotubes for high capacity battery materials. J. Mater. Chem. A 2015, 3 (16), 8832-8839.

Giuliano, M. W.; Lin, C.; Romney, D. K.; Miller, S. J.; Anslyn, E. V. A Synergistic Combinatorial and Chiroptical Study of Peptide Catalysts for Asymmetric Baeyer-Villiger Oxidation. Ind. Eng. Chem. Res. 2015, 357 (10), 2301-2309.

GHS Hazard and Precautionary Statements

Hazard Statements: H242-H272-H315-H319-H317-H335

Heating may cause a fire. May intensify fire; oxidizer. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.

Precautionary Statements: P221-P210-P220-P261-P280-P305+P351+P338-P405-P410-P411a+P235-P501a

Take any precaution to avoid mixing with combustibles. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Protect from sunlight. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
Packing Group
Harmonized Tariff Code


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