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Phenyl formate is widely used in the palladium-catalyzed carbonylation of aryl, alkenyl and allyl halides. It is also used as a reagent for the formylation of amines.
Reagent for the formylation of amines in high yield: J. Org. Chem., 36, 3238 (1971).
Ren, W.; Chang, W.; Wang, Y.; Li, J.; Shi, Y. Pd-Catalyzed Regiodivergent Hydroesterification of Aryl Olefins with Phenyl Formate. Org. Lett. 2015, 17 (14), 3544-3547.
Konishi, H.; Nagase, H.; Manabe, K. Concise synthesis of cyclic carbonyl compounds from haloarenes using phenyl formate as the carbonyl source. Chem. Commun. 2015, 51 (10), 1854-1857.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant