Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

L00302 Sulfur trioxide-trimethylamine complex, 95%

CAS Number
Trimethylamine-sulfur trioxide complex

Stock No. Size Price ($) Quantity Availability
L00302-14 25g 31.80
L00302-22 100g 84.60
L00302-36 500g 272.00
Add to Cart Bulk/Specialty Print Quote View Item

Sulfur trioxide-trimethylamine complex, 95%


Chemical Properties

Formula Weight
Melting point
ca 235° dec.
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.
Soluble in hot water and ethanol. Slightly soluble in dimethyl sulfoxide and methanol. Insoluble in water.


Sulfur trioxide-trimethylamine complex acts as a reagent for sulfonation and sulfamation reactions. It is used as a reactant for the synthesis of sulfate-conjugated resveratrol metabolites and chitooligosaccharides. It is used in association with dodecyl thioglycopyranoside, which acts as a surfactant for enantiomeric separation. Further, it acts as a nucleophile used for the preparation of alfa-tosyloxy ketones.


Moisture sensitive. Incompatible with strong oxidizing agents.

Literature References

Converts alcohols and phenols to their monosulfates under mild conditions: Ber., 57, 1045 (1924); J. Am. Chem. Soc., 74, 5212 (1952).

Reagent for the dehydration of oximes: Synthesis, 702 (1978).

Conditions have been described for the conversion of organolithiums in THF to sulfonic acids by insertion of SO3 into the C-Li bond: J. Org. Chem., 61, 1530 (1996):

Mans, D. J.; Ye, H.; Dunn, J. D.; Kolinski, R. E.; Long, D. S.; Phatak, N. L.; Ghasriani, H.; Buhse, L. F.; Kauffman, J. F.; Keire, D. A. Synthesis and detection of N-sulfonated oversulfated chondroitin sulfate in marketplace heparin. Anal. Biochem. 2015, 490, 52-54.

Jacquinet, J. C.; Lopin-Bon, C. Stereocontrolled preparation of biotinylated chondroitin sulfate E di-, tetra-, and hexasaccharide conjugates. Carbohydr. Res. 2015, 402, 35-43.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H314

Harmful if swallowed. Causes severe skin burns and eye damage.

Precautionary Statements: P260-P264b-P270-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
Packing Group
Harmonized Tariff Code


  • A10973

    N,N'-Dicyclohexylcarbodiimide, 99%
  • A12202

    Sulfur trioxide-pyridine complex, 98%, active SO3 ca 48-50%
  • A13348

    Phosphorus(V) oxide, 98%
  • A14708

    Di-tert-butyl dicarbonate, 97+%
  • A15364

    4-Methoxybenzaldehyde, 98%

Recently Viewed


Life Science

Metals & Materials


Analytical & Labware