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4-Nitrophenyl acetate is used with iodoacetic acid for reductive cleavage of methionine-containing peptides. It is also used as a substrate that has been used in assays for esterase and lipase activity. Inorganic complexes have been evaluated for their methanolysis or hydrolysis activity using p-nitrophenyl acetate.
John C. Hogan.; Richard D. Gandour. Fingerprinting a transition-structure guest by a building-block approach with an incremental series of catalytic hosts. Structural requirements for glyme and .alpha.,. µ. -dimethoxyalkane catalyses in N-methylbutylaminolysis and butylaminolysis of 4-nitrophenyl acetate in chlorobenzene. J. Org. Chem. 1992, 57, (1), 55-61.
Ik-Hwan Um.; Gwang-Ju Lee.; Hye-Won Yoon.; Dong-Sook Kwon. Solvent effect on rate for anionic nucleophilic substitution reaction of 4-nitrophenyl acetate in aqueous acetonitrile. Tetrahedron Letters. 1992, 33, (15), 2023-2026.
Reagent for the N-acylation of amines, e.g. basic amino acids: Can. J. Chem., 43, 991 (1965); 46, 1047 (1968).
Hazard Statements: H317-H318
May cause an allergic skin reaction. Causes serious eye damage.
Precautionary Statements: P261-P272-P280-P302+P352-P305+P351+P338-P310-P333+P313-P363-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant