Reacts with nitrile oxides, prepared in situ by the action of POCl3 on aliphatic nitro-compounds, to give 3-alkyl-5-methyl-4-isoxazolecarboxylates, useful in annulation (see Ethyl 3-ethyl-5-methylisoxazole-4-carboxylate, L00526): Org. Synth. Coll., 6, 592 (1988):/n
Hazard Statements: H315-H319
Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313
Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: