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L00537 Dimethyl acetylmethylphosphonate, 97%

CAS Number
4202-14-6
Synonyms
Acetylmethylphosphonic acid dimethyl ester
Dimethyl acetonylphosphonate

Stock No. Size Price ($) Quantity Availability
L00537-06 5g 91.40
L00537-14 25g 308.00
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Dimethyl acetylmethylphosphonate, 97%

MDL
MFCD00008769
EINECS
224-110-5

Chemical Properties

Formula
C5H11O4P
Formula Weight
166.12
Boiling Point
121-123°/11mm
Flash Point
93°(199°F)
Density
1.202
Refractive Index
1.4390
Storage & Sensitivity
Ambient temperatures.
Solubility
Difficult to mix.

Applications

Dimethyl acetylmethylphosphonate is a Reagent used together with tosyl azide in a one-pot alkynylation of aldehydes.

Notes

Protect from heat. Store away from oxidizing agents.

Literature References

Horner-Wadsworth-Emmons precursor of ɑß-unsaturated ketones.

For use of ß-ketophosphonates in an annulation sequence for building a cyclohexadienone ring onto a cyclic ketone, see: Synthesis, 855 (1982):

Successive treatment with NaH and n-BuLi gives the dianion which can be alkylated or acylated on the terminal position: see. e.g.: Synth. Commun., 22, 219 (1992); J. Chem. Soc., Perkin 1, 2259 (1998).

GHS Hazard and Precautionary Statements

Hazard Statements: H227

Combustible liquid.

Precautionary Statements: P210-P280-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1766218
Harmonized Tariff Code
2920.90
TSCA
No

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