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Dimethyl acetylmethylphosphonate is a Reagent used together with tosyl azide in a one-pot alkynylation of aldehydes.
Horner-Wadsworth-Emmons precursor of ɑß-unsaturated ketones.
For use of ß-ketophosphonates in an annulation sequence for building a cyclohexadienone ring onto a cyclic ketone, see: Synthesis, 855 (1982):
Successive treatment with NaH and n-BuLi gives the dianion which can be alkylated or acylated on the terminal position: see. e.g.: Synth. Commun., 22, 219 (1992); J. Chem. Soc., Perkin 1, 2259 (1998).
Hazard Statements: H227
Precautionary Statements: P210u-P280a-P370+P378a-P403+P235-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. In case of fire: Use for extinction: CO2, powder or water spray. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.