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N,N,N',N'-Tetramethyl-p-phenylenediamine is a reducing co-substrate for heme peroxidases. It is used for detection of peroxidases on polyacrylamide gels.
Powerful electron donor which readily forms stable, dark blue radical cation: J. Am. Chem. Soc., 61, 1981 (1939); 65, 1747 (1943), which is involved in a wide variety of redox reactions:
Electron acceptor in studies of catalytic properties of oxoreductases in cellular organelles: Anal. Biochem., 131, 404 (1983). Reducing agent for cytochrome c.
Hazard Statements: H302-H312-H332
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Precautionary Statements: P261-P280h-P304+P340-P301+P312a-P321-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Specific treatment (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.