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Trichloroacetic anhydride is used as a derivatization reagent involved in the analysis of amphetamine,methamphetamine and 3,4-methylenedioxymethamphetamine. It is also used in the determination of the metabolites of l-alpha-acetylmethadol (LAAM), such as noracetylmethadol, dinoracetylmethadol, methadol and normethadol by electron capture gas-liquid chromatography. It is used in the synthesis of trichloroacetonylpyridine by reacting with 2-methyl-pyridine.
Girard-Lauriault, P. L.; Unger, W. E.; Dietrich, P. M.; Holländer, A. Innovative and Established Strategies for the Surface Analysis of Nitrogen and Oxygen-Rich Plasma Polymer Films by XPS: An Introductory Guide. Plasma Processes Polym. 2015, 12 (9), 953-967.
Frenna, V.; Palumbo Piccionello, A.; Cosimelli, B.; Ghelfi, F.; Spinelli, D. The Boulton-Katritzky Reaction: A Kinetic Study of the Effect of 5-Nitrogen Substituents on the Rearrangement of Some (Z)-Phenylhydrazones of 3-Benzoyl-1, 2, 4-oxadiazoles. Eur. J. Org. Chem. 2014, 2014 (31), 7006-7014.
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.