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5538-51-2 - O-Acetylsalicyloyl chloride, 97% - 2-Acetoxybenzoyl chloride - Aspirin chloride - L00919 - Alfa Aesar

L00919 O-Acetylsalicyloyl chloride, 97%

CAS Number
5538-51-2
Synonyms
2-Acetoxybenzoyl chloride
Aspirin chloride

Size Price ($) Quantity Availability
25g 108.00
100g 243.00
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O-Acetylsalicyloyl chloride, 97%

MDL
MFCD00000663
EINECS
226-899-1

Chemical Properties

Formula
C9H7ClO3
Formula Weight
198.61
Melting point
47-50°
Boiling Point
134-136°/12mm
Flash Point
>110°(230°F)
Sensitivity
Moisture Sensitive
Solubility
Soluble in toluene. Reacts with water.

Applications

O-Acetylsalicyloyl chloride was used in the synthesis of enantiomerically pure bidentate heteroorganic ligands built on simple achiral skeletons and containing an aziridine moiety. It was used in the general synthesis of acetoxybenzamides. It was used in the chemical synthesis of 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)-aspirin conjugate via condensation reaction with 4-hydroxy-TEMPO. It was used as reagent in acylation of cyclobutenediones.

Notes

Moisture Sensitive. Store under dry inert gas. Store away from strong bases.

Literature References

Roger M. Smith; Asri Abdul Ghani; Declan G. Haverty; Gillian S. Bament; A.Y. Chamsi; Arnold G. Fogg. Derivatisation of amines with O-acetylsalicyloyl chloride to enhance electrochemical detection in high-performance liquid chromatography.Journal of Chromatography A.1988, 455 349-354.

Reagent for the conversion of diols into chloroalkyl acetates: Tetrahedron Lett., 1475 (1973), and for the conversion of pyrimidine nucleosides to their 2,2'-anhydro derivatives: Synthesis, 533 (1976). Compare 2-Acetoxyisobutyryl­ chloride, L00957.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H314-H318

Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
880372
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2918.22
TSCA
No

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