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O-Acetylsalicyloyl chloride was used in the synthesis of enantiomerically pure bidentate heteroorganic ligands built on simple achiral skeletons and containing an aziridine moiety. It was used in the general synthesis of acetoxybenzamides. It was used in the chemical synthesis of 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)-aspirin conjugate via condensation reaction with 4-hydroxy-TEMPO. It was used as reagent in acylation of cyclobutenediones.
Roger M. Smith; Asri Abdul Ghani; Declan G. Haverty; Gillian S. Bament; A.Y. Chamsi; Arnold G. Fogg. Derivatisation of amines with O-acetylsalicyloyl chloride to enhance electrochemical detection in high-performance liquid chromatography.Journal of Chromatography A.1988, 455 349-354.
Reagent for the conversion of diols into chloroalkyl acetates: Tetrahedron Lett., 1475 (1973), and for the conversion of pyrimidine nucleosides to their 2,2'-anhydro derivatives: Synthesis, 533 (1976). Compare 2-Acetoxyisobutyryl chloride, L00957.
Hazard Statements: H302-H314-H318
Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.