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40635-66-3 - 2-Acetoxyisobutyryl chloride, 98% - 2-Acetoxy-2-methylpropionyl chloride - 1-Chlorocarbonyl-1-methylethyl acetate - L00957 - Alfa Aesar

L00957 2-Acetoxyisobutyryl chloride, 98%

CAS Number
40635-66-3
Synonyms
2-Acetoxy-2-methylpropionyl chloride
1-Chlorocarbonyl-1-methylethyl acetate

Size Price ($) Quantity Availability
10g 64.70
50g 209.00
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2-Acetoxyisobutyryl chloride, 98%

MDL
MFCD00000708
EINECS
255-016-2

Chemical Properties

Formula
C6H9ClO3
Formula Weight
164.59
Boiling Point
55-56°/6mm
Flash Point
68°(154°F)
Density
1.150
Refractive Index
1.4290
Sensitivity
Moisture Sensitive

Literature References

Reagent for conversion of cis-1,2-diols, including nucleosides, via cyclic dioxolanone intermediates, into trans-chloroalkyl acetates. The reaction is selective for the 2'-OH of uridine derivatives and converts pyrimidine nucleosides to their anhydro forms: J. Am. Chem. Soc., 95, 4016 (1973). Application to synthesis of deoxy-sugars, by dechlorination with Bu3SnH: J. Chem. Soc., Chem. Commun., 677 (1978).

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Reaction of the chloroalkyl acetate (from a cis-glycol) with azide ion provides a route to the cis-amino alcohol: Tetrahedron Lett., 37, 2529 (1996). Compare O-Acetyl­salicyl­oyl­ chloride, L00919.

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GHS Hazard and Precautionary Statements

Hazard Statements: H227-H314-H318-H335

Combustible liquid. Causes severe skin burns and eye damage. Causes serious eye damage. May cause respiratory irritation.

Precautionary Statements: P210u-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
507772
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2918.99
TSCA
No

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  • L00919

    O-Acetylsalicyloyl chloride, 97%

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