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Ethyl 3-dimethylaminopropionate is used in the preparation of [3-(dimethylamino)propionyl]guanidine.
Alkyl 3-dimethylaminopropionates have been used as the synthetic equivalents of acrylate anions, by ɑ-lithiation, reaction with the appropriate electrophile and elimination: J. Org. Chem., 46, 4536 (1981):
Vanderveen, J. R.; Durelle, J.; Jessop, P. G. Design and evaluation of switchable-hydrophilicity solvents. Green Chem. 2014, 16, 1187-1197.
Zhi, Y.; Gao, L. X.; Jin, Y.; Tang, C. L.; Li, J. Y.; Li, J.; Long, Y. Q. 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B. Bioorg. Med. Chem. 2014, 22 (14), 3670-3683.
Hazard Statements: H226-H315-H319-H335
Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280g-P305+P351+P338
Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.