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Reacts with nucleophilic organosilanes, e.g. allyltrimethylsilane, TMS cyanide or silyl enol ethers, in the presence of a Lewis acid (ZnI2 or AlCl3) to give a series of ɑ-trifluoromethylated alcohols in high yield: Tetrahedron Lett., 33, 1351 (1992)./n
The synthesis of ɑ-trifluoromethylated alcohols has also been accomplished by In-mediated reaction with allylic bromides in water: Chem. Commun., 1929 (1996)./n
For a review applications in the synthesis of trifluoromethylated compounds, see: Current Org. Chem., 8, 1659 (2004)./n
Hazard Statements: H226-H302-H315-H319
Flammable liquid and vapour. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: P210-P280a-P280a-P303+P361+P353-P305+P351+P338-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Dispose of contents/container in accordance with local/regional/national/international regulations.