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18871-66-4 - N,N-Dimethylacetamide dimethyl acetal, tech. 90%, stab with 5-10% methanol - L01642 - Alfa Aesar

L01642 N,N-Dimethylacetamide dimethyl acetal, tech. 90%, stab with 5-10% methanol

CAS Number
18871-66-4
Synonyms

Size Price ($) Quantity Availability
5g 44.40
25g 124.00
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N,N-Dimethylacetamide dimethyl acetal, tech. 90%, stab with 5-10% methanol

MDL
MFCD00008476
EINECS
242-641-0

Chemical Properties

Formula
C6H15NO2
Formula Weight
133.19
Boiling Point
118-120°
Flash Point
8°(46°F)
Density
0.911
Refractive Index
1.4120
Sensitivity
Moisture Sensitive
Solubility
Hydrolyzes in water.

Applications

N,N-Dimethylacetamide dimethyl acetal is used as a reagent for the synthesis of amides, diacylamines, and heterocycles, one carbon inserting synthon in preparation of pyrimido[1,2-a][1,3,5]triazin-6-ones. It is used as intermediate in building block.

Notes

Moisture Sensitive. Store at 2 - 8°C. Incompatible with strong oxidizing agents, Acids.

Literature References

Richard K. Hill; Raghovan. Soman; Seiji. Sawada. Asymmetric induction in the thermal reactions of allylic alcohols with N,N-dimethylacetamide dimethylacetal and triethyl orthoacetate.J. Org. Chem.1972, 37 (23), 3737-3740.

Robert G. Salomon, Swadesh R. Raychaudhuri. Convenient preparation of N,N-dimethylacetamide dimethyl acetal.J. Org. Chem.1984, 49 (19), 3659-3660.

Reacts with 1,2-diols, e.g. sugars, to form 1-(dimethylamino)ethylidene cyclic acetals which can be cleaved with aqueous AcOH, giving the monoacetate of the less hindered OH, thus providing a method for selective monoprotection of the diol: Can. J. Chem., 50, 233 (1972).

Reacts with active methylene compounds to give the (dimethylamino)ethylidene derivatives: Liebigs Ann. Chem., 641, 1 (1961), compare N,N-Dimethyl­formamide dimethyl­ acetal, A15350.

For use in the N-acetylation of amides to give diacylamines (imides) in high yield, see: Synthesis, 119 (1980).

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H302-H312-H332-H315-H319-H370-H335

Highly flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. Causes damage to organs. May cause respiratory irritation.

Precautionary Statements: P210-P260-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1420865
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2922.50
TSCA
No

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