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2-Acetamidoacrylic acid is used as an antioxidant as well as a monomer.
Pd-catalyzed arylation by aryl bromides affords pure (Z)-isomers of derivatives of dehydrophenylalanine: Tetrahedron Lett., 24, 4603 (1983).
For asymmetric hydrogenation using a chiral Rh catalyst, see: Chem. Lett., 305 (1989).
Reacts with pyrazole in the presence of acetic acid or an acetate buffer to give 2-acetamido-3-(N-pyrazolo)propionic acid which, on hydrolysis, gives the pyrazoloalanine, an unusual naturally occurring amino acid: Chem. Pharm. Bull., 70, 609 (1972):
Pàmies, O.; Diéguez, M.; Bäckvall, J. E. Artificial Metalloenzymes in Asymmetric Catalysis: Key Developments and Future Directions. Adv. Synth. Catal. 2015, 357 (8), 1567-1586.
Zhan, E.; Chen, C.; Li, Y.; Shen, W. Heterogeneous asymmetric hydrogenation over chiral molecule-modified metal particles. Catal. Sci. Technol. 2015, 5 (2), 650-659.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.