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6-(Methylthio)purine can react with 1-bromo-2-chloro-ethane to produce 6-methylsulfanyl-9-vinyl-9H-purine. This reaction will need reagent NaOH, catalyst (C8H17)4NBr, and the menstruum benzene and H2O.
Roland K. Robins. Potential Purine Antagonists. XV. Preparation of Some 6,8-Disubstituted Purines. J. Am. Chem. Soc. 1958, 80, (24), 6671-6679.
B.S. Tay.; R.McC. Lilley.; A.W. Murray.; M.R. Atkinson. Inhibition of phosphoribosyl pyrophosphate amidotransferase from Ehrlich ascites-tumour cells by thiopurine nucleotides. Biochemical Pharmacology. 1969, 18, (4), 936-938.