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4270-27-3 - 6-Chlorouracil, 98+% - 6-Chloro-2,4-dihydroxypyrimidine - 4-Chlorouracil - L01875 - Alfa Aesar

L01875 6-Chlorouracil, 98+%

CAS Number
4270-27-3
Synonyms
6-Chloro-2,4-dihydroxypyrimidine
4-Chlorouracil

Size Price ($) Quantity Availability
1g 47.28
5g 144.20
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6-Chlorouracil, 98+%

MDL
MFCD00014595
EINECS
224-258-0

Chemical Properties

Formula
C4H3ClN2O2
Formula Weight
146.53
Melting point
ca 295° dec.
Solubility
Soluble in Ammonium Hydroxide

Applications

Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Hongdeng Qiu.; Shengxiang Jiang.; Xia Liu. N-Methylimidazolium anion-exchange stationary phase for high-performance liquid chromatography. Journal of Chromatography A. 2006, 1103, (2), 265-270.

Troy Voelke.; Tim Ewell.; Jean Joo.; Eric D. Edstrom. o-Nitrobenzyl as a photocleavable nitrogen protecting group for indoles, benzimidazole, and 6-chlorouracil. Tetrahedron Letters. 1998, 39, (5-6), 359-362.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
120492
Harmonized Tariff Code
2933.59
TSCA
No

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