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Nicotinic hydrazide is used in hydrazone library formation. It is used to study the oxidation of isonicotinic acid hydrazide (ionized) by horseradish peroxidase. Nicotinic hydrazide is an inhibitor of peroxidase enzyme. It forms solid metal complexes having strong biological activity
Kai Johnsson.; Peter G. Schultz. Mechanistic Studies of the Oxidation of Isoniazid by the Catalase Peroxidase from Mycobacterium tuberculosis. J. Am. Chem. Soc. 1994, 116, (16), 7425-7426.
M.M.Abou Sekkina.; M.G.Abou El-Azm. Thermo-chemical behavior of solid nicotinic hydrazide metal complexes in correlation with their stoichiometry. Thermochimica Acta. 1984, 77, (1-3), 211-218.
Hazard Statements: H315-H319-H335-H351
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Suspected of causing cancer.
Precautionary Statements: P201-P202-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. If skin irritation occurs: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant