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60-31-1 - Acetylcholine chloride, 98+% - 2-Acetoxy-N,N,N-trimethylethanium chloride - 2-Acetyloxy-N,N,N-trimethylethanium chloride - L02168 - Alfa Aesar

L02168 Acetylcholine chloride, 98+%

CAS Number
60-31-1
Synonyms
2-Acetoxy-N,N,N-trimethylethanium chloride
2-Acetyloxy-N,N,N-trimethylethanium chloride

Size Price ($) Quantity Availability
25g 40.99
100g 116.33
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Acetylcholine chloride, 98+%

MDL
MFCD00011698
EINECS
200-468-8

Chemical Properties

Formula
CH3CO2CH2CH2N(CH3)3Cl
Formula Weight
181.66
Melting point
149-152°
Sensitivity
Hygroscopic
Solubility
Soluble in water (600 g/L at 20°C), alcohol, DMSO (36 mg/ml at 25°C), and ethanol (36 mg/ml at 25°C). Insoluble in ether.

Applications

Acetylcholine chloride acts as an endogenous neurotransmitter at cholinergic synapses. The compound has been shown to have ophthalmological uses and can be broken down quickly by choliesterases. Acetylcholine influences many basic cells functions, such as mitosis, cells differentiation, cytoskeletal organization, and cell to cell contact, among other functions. It reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis.The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Notes

Store away from moisture. Store under dry inert gas. Incompatible with heat,oxidizing agents.

Literature References

John K. Herdklotz; Ronald L. Sass. The crystal structure of acetylcholine chloride: A new conformation for acetylcholine.Biochemical and Biophysical Research Communication.1970, 40 583-588.

Rafael Lorente De Nó. Effects of choline and acetylcholine chloride upon peripheral nerve fibers.Journal of Cellular and Comparative Physiology.1944, 24 85-97.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335-H303

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May be harmful if swallowed.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,87
Beilstein
3571875
Harmonized Tariff Code
2923.90
TSCA
Yes
RTECS
FZ9800000

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