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19012-03-4 - 1-Methylindole-3-carboxaldehyde, 98+% - 3-Formyl-1-methylindole - L02212 - Alfa Aesar

L02212 1-Methylindole-3-carboxaldehyde, 98+%

CAS Number
19012-03-4
Synonyms
3-Formyl-1-methylindole

Size Price ($) Quantity Availability
1g 28.30
5g 80.60
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1-Methylindole-3-carboxaldehyde, 98+%

MDL
MFCD00014570
EINECS
242-750-3

Chemical Properties

Formula
C10H9NO
Formula Weight
159.19
Melting point
67-71°
Sensitivity
Air Sensitive
Solubility
Insoluble in water.

Applications

1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. Store under dry inert gas. It is sensitive to air.

Literature References

Ahmed Abouabdellah.; Robert H. Dodd. A new approach to the synthesis of functionalized pyrido[2,3-b]indoles by way of a palladium-catalyzed ring closing reaction between the N-1 and C-9a positionsn. Tetrahedron Letters. 1998, 31 (15), 2119-2122.

Haiming Zhang.; Richard C Larock. Synthesis of β- and γ-carbolines by the palladium/copper-catalyzed coupling and copper-catalyzed or thermal cyclization of terminal acetylenes. Tetrahedron Letters. 2002, 43(8), 1359-1362.

Other References

Beilstein
121302
Harmonized Tariff Code
2933.99
TSCA
No

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