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2-Acetylcyclohexanone is useful for synthesis of anilinoethanolamines, 1-(pyridyl)ethanol derivatives that can reduce keto-esters and ketones. It is also used in the synthesis of phenothiazine derivatives that can inhibit prote in farnesyltransferase molecules and some that show anti-proliferative activity.
Emilia Iglesias. Tautomerization of 2-Acetylcyclohexanone. 1. Characterization of Keto-Enol/Enolate Equilibria and Reaction Rates in Water.J. Org. Chem.2003, 68 (7), 2680-2688.
Fillmore Freeman; Donald K. Fraquhar; Robert L. Walker. Reaction of 2-acetylcyclohexanone with malononitrile and cyanoacetamide.J. Org. Chem.1968, 33 (9), 3648-3650.
For conversion to the ɑß-unsaturated diketone by selenoxide elimination, see Phenylselenenyl chloride, A12751.
Hazard Statements: H227
Precautionary Statements: P210-P280-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant