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Abolishes the rapid inactivation of membrane sodium- and potassium-ion channels.
D R Matteson; and P Carmeliet. Modification of K channel inactivation by papain and N-bromoacetamide. Biophysical Journal., 1988,53(4), 641-645.
J Tanguy and J Z Yeh. BTX modification of Na channels in squid axons. I. State dependence of BTX action. Journal of General Physiology., 1991,97(3), 499-519.
Source of positive bromine, useful for the conversion of alkenes to bromohydrins under mild conditions: Helv. Chim. Acta, 26, 562, 746, 1799 (1943); Tetrahedron Lett., 765 (1973). It is also a useful reagent for mild oxidation of secondary alcohols to ketones: J. Biol. Chem., 184, 393 (1950); J. Am. Chem. Soc., 76, 3682 (1954); 85, 1409 (1963).
In combination with AgOAc and AcOH, has been used to convert alkenes stereoselectively to cis-1,2-diols: Tetrahedron Lett., 1581 (1976).
Hazard Statements: H314-H319-H335
Causes severe skin burns and eye damage. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280-P303+P361+P353-P305+P351+P338-P310a
Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor