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500-38-9 - Nordihydroguaiaretic acid, 97% - 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane - L03149 - Alfa Aesar

L03149 Nordihydroguaiaretic acid, 97%

CAS Number
500-38-9
Synonyms
1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane

Size Price ($) Quantity Availability
1g 63.76
5g 228.11
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Nordihydroguaiaretic acid, 97%

MDL
MFCD00002206
EINECS
207-903-0

Chemical Properties

Formula
C18H22O4
Formula Weight
302.37
Melting point
184-188°
Solubility
Soluble in 100% ethanol, methanol, acetone, dimethylsulfoxide, dimethylformamide, ethanol (5% w/v), glycol, PEG, and slightly soluble in hot water. Insoluble in water.

Applications

Nordihydroguaiaretic acid used as a nutritional supplement, as food additive, and in herbal medicine. It is used in the treatment of multiple diseases, including cardiovascular diseases, neurological disorders and cancers. It is also used as an antioxidant.

Notes

Incompatible with oxidizing agents.

Literature References

Naturally-occurring antioxidant.

Paracatu, L. C.; de Faria, C. M. Q. G.; Zeraik, M. L.; Quinello, C.; Rennó, C.; Palmeira, P.; da Fonseca, L. M.; Ximenes, V. F. Hydrophobicity and antioxidant activity acting together for the beneficial health properties of nordihydroguaiaretic acid. Food Funct. 2015, 6, 1818-1831.

Ibrahim, N. H.; Gregoire, M.; Devassy, J. G.; Wu, Y.; Yoshihara, D.; Yamaguchi, T.; Nagao, S.; Aukema, H. M. Cyclooxygenase product inhibition with acetylsalicylic acid slows disease progression in the Han: SPRD-Cy rat model of polycystic kidney disease. Prostaglandins Other Lipid Mediat. 2015, 116, 19-25.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P280h-P305+P351+P338

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Merck
14,6693
Beilstein
2056825
Harmonized Tariff Code
2907.29
TSCA
No
RTECS
UX1750000

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