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4-Cyclohexylaniline is used as a starting material for the preparation of 1-cyclohexyl-4-nitroso-benzene. It is used as a reactant in nucleophilic acylation to form N-(4-cyclohexylphenyl)acetamide by reacting with acetyl halides. It is also involved in the synthesis of N-(4-cyclohexylphenyl)-2-morpholino-acetamide by reaction with 2-morpholinoacetyl fluoride. Further, it reacts with 4-bromo-4-oxo-butanoic acid to get 4-[(4-cyclohexylphenyl)amino]-4-oxo-butanoic acid.
Mou, J.; Park, A.; Cai, Y.; Yuan, J.; Yuan, C. Structure-activity relationship study of E6 as a novel necroptosis inducer. Bioorg. Med. Chem. Lett. 2015, 25 (15), 3057-3061.
Wei, W.; Wen, J.; Yang, D.; Sun, X.; You, J.; Suo, Y.; Wang, H. Iron-catalyzed three-component tandem process: a novel and convenient synthetic route to quinoline-2,4-dicarboxylates from arylamines, glyoxylic esters, and alpha-ketoesters. Tetrahedron 2013, 69 (50), 10747-10751.
Hazard Statements: H302-H312
Harmful if swallowed. Harmful in contact with skin.
Precautionary Statements: P280h
Wear protective gloves/clothing.